Rejection of Experimental Hodgkins Lymphoma by T-Cells Engineered with a CD19 Chimeric Antigen Receptor
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منابع مشابه
Rejection of Experimental Hodgkins Lymphoma by T-Cells Engineered with a CD19 Chimeric Antigen Receptor
T cells engineered to express chimeric antigen receptors (CARs) combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) signaling domain for triggering cell activation are being used for immunotherapeutic targeting of tumor cells in a non-HLA restricted manner. In this study we transduced T cells with a CD19-CAR construct containing a truncated CD34 gene (tCD34) marker...
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Clinical use of CD19-redirected chimeric antigen-receptor (CD19 CAR) T cell therapy has shown promise in the treatment of various B cell malignancies including acute lymphoblastic leukemia (ALL) and non-Hodgkin’s lymphoma (NHL). However, its clinical use is limited due to inherent or acquired resistance of tumor cells to apoptotic death signals delivered by CAR transduced T cells as well as by ...
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ژورنال
عنوان ژورنال: Journal of Cancer Therapy
سال: 2012
ISSN: 2151-1934,2151-1942
DOI: 10.4236/jct.2012.35071